Which of the following is considered a controlled substance document that must be reported if stolen or lost?

• A. Completed DEA 222 forms
• B. Unfilled Rx in 'on hold' files
• C. Both A and B
• D. Prescription labels on bottles

Answer: (C)

The main idea is that any theft or loss of documentation related to controlled substances must be reported to the DEA to prevent diversion. Completed DEA 222 forms are the official record used to order or transfer Schedule I–II substances; if those forms are stolen, they could be misused to obtain controlled substances, so reporting is required. Unfilled prescriptions that are held in “on hold” files are still part of the controlled-substance record-keeping and could enable misuse if they’re stolen, so they also must be reported. Prescription labels on bottles, by contrast, aren’t themselves a reportable document for theft or loss. They don’t create a separate reporting obligation, whereas the actual documents that govern possession and dispensing of controlled substances do.